“Tranq Dope” Spreading Across US

All of the information on this page has been reviewed and fact-checked by an addiction expert.

All of the information on this page has been reviewed and fact-checked by an addiction expert.

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The FDA is investigating reports that animal tranquilizers are mixed with heroin and fentanyl, a horrifying mixture named Tranq Dope. When Xylazine, a tranquilizer used for horses, is combined with fentanyl, the two substances become extremely dangerous and life-threatening.

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Is Tranq Dope Narcan Resistant?

Tranq Dope can cause complications during overdose because it appears that naloxone, a medication used to revive overdose victims, isn’t effective when used to combat a Tranq Dope.

The FDA reports1 that the symptoms of suffering Xylazine exposure are similar to those one would experience during an opioid overdose. This makes it difficult for doctors and nurses who may not know how much tranquilizer was mixed into their patient’s drugs, putting them at risk more than just taking opioids.

Here are some facts about Tranq Dope that you should know:

  1. It’s an animal tranquilizer, but not for humans, as it has strong central nervous system depression. It doesn’t respond to naloxone and can be life-threatening if you have a bad reaction or are allergic – even once!
  2. The overdose victim may be unresponsive but still breathing.
  3. If someone requires naloxone and it is administered, they are more likely to need rescue breaths.
  4. The likelihood of not breathing increases when these drugs are used in conjunction.

Physical Effects of Tranq Dope

An article by Fox 292 also shares reports from individuals who have used the mixture, saying their skin turned into an ulcerated lesion after injection. One woman’s bone could be seen through these types of sores, while others claim they deterred others away with gory images on Reddit’s r/opiates subforum, often created as warning signs for potential users. The physical effects are:
  • Tranq Dope is a very dangerous drug that can cause severe infections to the skin and tissue of your fingers, toes, etc, leading not only to an increase in amputations but also box generations!
  • These wounds can occur regardless of how the drug is administered
  • It is possible that some wounds occur due to injection sites, but it’s more likely they happen at random on different parts of your body (in no logical pattern or order)
  • People who are immunocompromised have a higher likelihood of developing these horrifying wounds.
  • However, other users don’t get wounds at all.

Get Help for Fentanyl Addiction

If you or someone you know is using Tranq Dope, it’s time to get help and start a new life in recovery.  Cornerstone Healing Center can help. We are a Scottsdale, AZ, treatment center specializing in treating Fentanyl addiction.


[1] FDA alerts health care professionals of risks to patients exposed to xylazine in illicit drugs [2] Tranq Dope: Advocacy groups warn of powerful drug gaining popularity in Philadelphia

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Susana is a recovery, mental health, and addiction education enthusiast with 8 years of experience in addiction recovery herself. Susana holds a Bachelor of Arts from the GCU College of Theology. She is anti-addiction stigma and believes accurate and factual information is essential to beginning the recovery process.
lionel estrada lisac clinical director



Lionel, a Licensed Independent Substance Abuse Counselor (LISAC) with over 4 years at Cornerstone. Passionate about helping those with addiction, he has trained as an EMDR therapist  adopting a trauma-informed approach to treat the underlying issues of addiction, providing an empathetic approach to addiction.

Articles written prior to August 2023 were also clinically reviewed by Karen Williams, LPC 

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